Kitasato Saburo

Who's Who

1852 Nian 10 Yue 20 was born in Japan Higo (now Kumamoto Prefecture) Aso-gun small country rural North Village generations manor home, in 1866 began studying Sinology. 1872 Kumamoto into the new medical school, the University of Tokyo School of Medicine in 1875, received his MD in 1883, the Ministry of Home Affairs Health Bureau Tokyo trials office. At this point, an associate professor of the University of Tokyo Ogata regular day back from Germany, Japan built the first bacteriology laboratory, either the North began his assistant. 1884 Nagasaki cholera, North proved the existence of pathogenic bacteria Vibrio cholerae ── under the microscope. 1885 ~ 1891 went to Germany to study, work under the guidance of the famous bacteriologist Robert Koch, and Koch forged a profound friendship between teachers and students. During this period he published several papers milestone in the history of bacteriology. Scholars generally believe that anaerobic bacteria was only grow in symbiosis with other bacteria environment, but can not obtain pure cultures.

He discovered the cause of the plague bacillus, and made important contributions to the study of other diseases. After 1883, he received his medical degree from the University of Tokyo, to work in North Central Bureau of Ministry of Public Health. In 1885, the government sent him to Berlin, Germany's Robert Koch (Robert Koch) bacteriology laboratory to learn advanced technology. In 1889, in the North, where success leads to cultivate Bacillus tetanus. In 1890, he and his German colleague Emil von Behring (Emil von Behring) joint research that can be achieved by injection of immune serum against tetanus containing antimycin. And this antimycin in animal blood is exposed to the environment tetani generated. In the same year, Behring and Kitasato will this method of immunology applied to the treatment of diphtheria and tetanus, and published a paper landmark, opened a new field of serology. Before leaving Berlin North also studied tuberculin Koch discovered in 1890. Since the North of these achievements, the University of Berlin awarded him an honorary professor title.

2019 Nian 4 9, the Japanese government with financial Taro Aso formally announced that it will replace banknotes patterns in the first half year of 2024, the introduction of 10,000 yen, 5000 yen and 1000 yen new notes, the use portraits were positive Shibusawa Eiichi, Tsuda Umeko, Kitasato Shibasaburō of.

published works

After 1889 years ago, the author discusses North anaerobic Clostridium culture method, proposed bacteria can grow in the medium under a fixed hydrogen-containing atmosphere surrounded by. Bacillus strong heat resistance, can withstand atmospheric pressure temperature 80 deg.] C. He will mixed with other tetanus bacterial culture was heated to 80 ℃ 45 ~ 50 minutes and then placed in a hydrogen-containing atmosphere culture was continued, thereby obtaining a pure culture of Clostridium tetani first strain. North extracted tetanus toxin diluted, gradually increase the amount repeatedly injected into animals, so animals can get proof of passive immunization, antisera produced by immunization in animals immunized animals can not produce the prevention and treatment of tetanus infection. In 1890, Emil von Behring and successfully tested with pure cultures of the world on the first Cui tetanus bacteria, and later North and Emil von Behring jointly published papers about tetanus and diphtheria immunization.


opened up serological this new field of science, 1892 back to Japan, Fukuzawa Yukichi and others in helping to create a large membership Health Association of Japan private Institute of infectious diseases, founding director, research on infectious diseases and bacteriology in Japan take the lead.

1893, in order to tuberculosis patients receiving treatment, he established the Health Park, and served as principal. In 1894, during the bubonic plague occurred in Hong Kong, he was ordered in May, kai Aoyama Tanemichi, who went to the affected areas to carry out field surveys, and in June with the Swiss bacteriologist Alexander - En Mier - John respective Yersinia isolated the causative agent of this disease - Yersinia pestis.

1897 years, the Kitasato founded the Kitasato Institute of Bacteriology, he began to engage in bacteriological research dysentery. In 1898, the Japanese bacteriologist Kiyoshi Shiga Under his proposal, separate from dysentery patient's feces out of Shigella, which is now (Shigella).

1914, when he changed to the Institute of the National Institutes of Tokyo Imperial University and hand over management, he resigned as director of the office, and in 1923 was president of the Japan Medical Association, was closed in 1924 Baron, and became Bachelor Academy, House of Lords, Mr Royal Society, and an honorary member of the American and German some of the Society. He is the editor of the magazine "North Experimental Medicine." He has published many papers bacteriological aspects. Chung died in Gunma Prefecture City June 13, 1931.

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